ApoE epsilon4 is not associated with posictal confusion in patients with mesial temporal lobe epilepsy with hippocampal sclerosis

Epilepsy Res. 2009 Aug;85(2-3):311-3. doi: 10.1016/j.eplepsyres.2009.03.012. Epub 2009 Apr 16.


A previous report found an association between ApoE isoforms and postictal confusion in medically intractable temporal lobe epilepsy (TLE). We performed a molecular epidemiology study in an independent sample of 77 TLE patients. We failed to replicate the original allelic association between ApoE epsilon4 allele and postictal confusion in our population (chi(2)=1.67; d.f.=1; p=0.2). Thus, the association between ApoE epsilon4 allele and postictal confusion still needs to be fully investigated in different and independent populations.

MeSH terms

  • Apolipoproteins E / genetics*
  • Argentina / epidemiology
  • Confusion / epidemiology
  • Confusion / etiology*
  • Confusion / genetics*
  • DNA / genetics
  • Epilepsy, Temporal Lobe / complications*
  • Epilepsy, Temporal Lobe / genetics*
  • Gene Frequency
  • Genotype
  • Hippocampus / pathology*
  • Humans
  • Polymorphism, Restriction Fragment Length
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sclerosis
  • Seizures / psychology*


  • Apolipoproteins E
  • DNA