The calcium/NFAT pathway: role in development and function of regulatory T cells

Microbes Infect. 2009 Apr;11(5):612-9. doi: 10.1016/j.micinf.2009.04.008. Epub 2009 Apr 16.


Calcium signals are essential for diverse cellular functions in the immune system. Sustained Ca(2+) entry is necessary for complete and long-lasting activation of calcineurin/NFAT pathways. A growing number of studies have emphasized that Ca(2+)/calcineurin/NFAT pathway is crucial for both development and function of regulatory T cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Calcineurin / metabolism*
  • Calcium / metabolism*
  • Humans
  • Models, Biological
  • NFATC Transcription Factors / metabolism*
  • T-Lymphocytes, Regulatory / physiology*


  • NFATC Transcription Factors
  • Calcineurin
  • Calcium