Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents

J Pediatr. 2009 Jun;154(6):807-13. doi: 10.1016/j.jpeds.2009.01.015. Epub 2009 Apr 17.


Objective: To evaluate whether sugar-sweetened beverage consumption, a significant source of dietary fructose, is associated with higher serum uric acid levels and blood pressure in adolescents.

Study design: We analyzed cross-sectional data from 4867 adolescents aged 12 to 18 years in the National Health and Nutrition Examination Survey, 1999-2004. Dietary data were assessed from 24-hour dietary recall interviews. Sugar-sweetened beverages included fruit drinks, sports drinks, soda, and sweetened coffee or tea. We used multivariate linear regression to evaluate the association of sugar-sweetened beverage consumption with serum uric acid and with blood pressure.

Results: Adolescents who drank more sugar-sweetened beverages tended to be older and male. In the adjusted model, serum uric acid increased by 0.18 mg/dL and systolic blood pressure z-score increased by 0.17 from the lowest to the highest category of sugar-sweetened beverage consumption (P for trend, .01 and .03, respectively).

Conclusions: These results from a nationally representative sample of US adolescents indicate that higher sugar-sweetened beverage consumption is associated with higher serum uric acid levels and systolic blood pressure, which may lead to downstream adverse health outcomes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Beverages / adverse effects*
  • Black or African American
  • Blood Pressure / drug effects*
  • Body Mass Index
  • Child
  • Diet
  • Energy Intake
  • Female
  • Fructose / adverse effects*
  • Hispanic or Latino
  • Humans
  • Hypertension / blood
  • Hypertension / chemically induced
  • Life Style
  • Male
  • Sweetening Agents / adverse effects*
  • Uric Acid / blood*


  • Sweetening Agents
  • Uric Acid
  • Fructose