Recurrent acute kidney failure due to McArdle disease

Iran J Kidney Dis. 2008 Oct;2(4):234-6.


We present an adolescent with McArdle disease and recurrent acute kidney failure due to rhabdomyolysis. The patient was admitted with acute kidney failure for 3 times and due to a history of proximal weakness, fatigue, and muscular cramps after physical activities a glycogen-storage disease was suspected. Serum creatine phosphokinase and urine myoglobin were found to be elevated. McArdle disease was diagnosed based on pathologic examination of muscle tissue specimen. Patients presenting with rhabdomyolysis following strenuous exercise should be evaluated for McArdle disease.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / etiology*
  • Acute Kidney Injury / therapy
  • Adolescent
  • Child
  • Electromyography
  • Glycogen Storage Disease Type V / complications*
  • Glycogen Storage Disease Type V / diagnosis*
  • Humans
  • Male
  • Recurrence
  • Renal Dialysis
  • Rhabdomyolysis / etiology