Microtubule assembly, organization and dynamics in axons and dendrites

Nat Rev Neurosci. 2009 May;10(5):319-32. doi: 10.1038/nrn2631.


During the past decade enormous advances have been made in our understanding of the basic molecular machinery that is involved in the development of neuronal polarity. Far from being mere structural elements, microtubules are emerging as key determinants of neuronal polarity. Here we review the current understanding of the regulation of microtubule assembly, organization and dynamics in axons and dendrites. These studies provide new insight into microtubules' function in neuronal development and their potential contribution to plasticity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Axons / physiology*
  • Cell Polarity
  • Dendrites / physiology*
  • Microtubules / physiology*
  • Neuronal Plasticity / physiology
  • Neurons / cytology*
  • Neurons / physiology
  • Nonlinear Dynamics
  • Synapses / physiology