T-cell-dependent accumulation of eosinophils in the lung and its inhibition by monoclonal anti-interleukin-5

Int Arch Allergy Appl Immunol. 1991;94(1-4):171-3. doi: 10.1159/000235354.

Abstract

The transnasal administration of an extract of the parasite Ascaris suum to C57BL/6 mice for 3 weeks produced marked eosinophilia in the bronchoalveolar lavage (BAL) fluid. The oral administration of ciclosporin significantly suppressed the pulmonary eosinophilia. Athymic C57BL/6-nu/nu mice failed to develop pulmonary eosinophilia. These data indicate that the pulmonary eosinophilia caused by this parasite extract is T-cell-dependent. Genetically mast-cell-deficient (WB x C57BL/6) F1-W/Wv (W/Wv) mice developed marked eosinophilia in the BAL, which shows that mast cells are not necessary in the formation of lung eosinophilia in this model. Monoclonal antimurine interleukin-5 injected intraperitoneally clearly inhibited the infiltration of eosinophils in the lung, suggesting that T-cell-derived interleukin-5 is essential.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology*
  • Interleukin-5 / immunology
  • Interleukin-5 / physiology*
  • Lung / pathology*
  • Male
  • Mast Cells / physiology
  • Mice
  • Mice, Inbred C57BL
  • Pulmonary Eosinophilia / etiology*
  • Pulmonary Eosinophilia / prevention & control
  • T-Lymphocytes / physiology*

Substances

  • Antibodies, Monoclonal
  • Interleukin-5