Clavatadines C-E, guanidine alkaloids from the Australian sponge Suberea clavata

Malcolm S Buchanan; Anthony R Carroll; Deborah Wessling; Michael Jobling; Vicky M Avery; Rohan A Davis; Yunjiang Feng; John N A Hooper; Ronald J Quinn

doi:10.1021/np8008013

Clavatadines C-E, guanidine alkaloids from the Australian sponge Suberea clavata

J Nat Prod. 2009 May 22;72(5):973-5. doi: 10.1021/np8008013.

Authors

Malcolm S Buchanan¹, Anthony R Carroll, Deborah Wessling, Michael Jobling, Vicky M Avery, Rohan A Davis, Yunjiang Feng, John N A Hooper, Ronald J Quinn

Affiliation

¹ Eskitis Institute, Griffith University, Brisbane, Queensland 4111, Australia.

PMID: 19379003
DOI: 10.1021/np8008013

Abstract

Three new marine alkaloids, clavatadines C-E (1-3), together with the three known compounds aerophobin 1 (4), purealdin L (5), and aplysinamisine II (6) were isolated from extracts of the sponge Suberea clavata by bioassay-guided fractionation using a serine protease factor XIa assay. Their structures were determined by 1D and 2D NMR spectroscopy. Compounds 1-6 exhibited weak inhibition of factor XIa.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification*
Alkaloids / pharmacology
Animals
Australia
Factor XIa / antagonists & inhibitors
Guanidines / chemistry
Guanidines / isolation & purification*
Guanidines / pharmacology
Marine Biology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Porifera / chemistry*

Substances

Alkaloids
Guanidines
clavatadine C
clavatadine D
clavatadine E
Factor XIa