Th17 cells bounce off the fungal wall

Cell Host Microbe. 2009 Apr 23;5(4):311-3. doi: 10.1016/j.chom.2009.04.004.

Abstract

Th17 cells are thought to play a pivotal role in defenses against Candida albicans. van de Veerdonk et al. (2009) investigate components of the fungal cell wall and their cognate receptors on human peripheral blood mononuclear cells (PBMCs) responsible for IL-17 production and find a predominant role for mannan stimulation of the mannose receptor.

Publication types

  • Comment

MeSH terms

  • Candida albicans / immunology*
  • Cell Wall / immunology
  • Humans
  • Lectins, C-Type / metabolism
  • Leukocytes, Mononuclear / immunology*
  • Leukocytes, Mononuclear / microbiology*
  • Mannans / immunology
  • Mannose Receptor
  • Mannose-Binding Lectins / metabolism
  • Models, Biological
  • Receptors, Cell Surface / metabolism
  • T-Lymphocytes, Helper-Inducer / immunology*

Substances

  • Lectins, C-Type
  • Mannans
  • Mannose Receptor
  • Mannose-Binding Lectins
  • Receptors, Cell Surface