Molecular aspects of tumour hypoxia

Mol Oncol. 2008 Jun;2(1):41-53. doi: 10.1016/j.molonc.2008.03.006. Epub 2008 Mar 27.


Hypoxia is an important feature of the microenvironment of a wide range of solid tumours. Its critical role in radio- and chemoresistance and its significance as an adverse prognostic factor have been well established over the last decades. On a cellular level, hypoxia evokes a complex molecular response with a central role for the HIF-1 pathway. The cellular processes under control of HIF-1 contain important prognostic information and comprise potential candidates for directing hypoxia-modifying therapies. This review will provide an overview of the current knowledge on the molecular aspects of tumour hypoxia and the link to clinical practice.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Drug Delivery Systems
  • Humans
  • Hypoxia / drug therapy
  • Hypoxia / etiology*
  • Hypoxia-Inducible Factor 1 / metabolism
  • Neoplasms / drug therapy
  • Neoplasms / pathology*
  • Prognosis


  • Hypoxia-Inducible Factor 1