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Review
. 2009 May;67(5):284-8.
doi: 10.1111/j.1753-4887.2009.00200.x.

Into the Matrix: Regulation of the Iron Regulatory Hormone Hepcidin by matriptase-2

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Review

Into the Matrix: Regulation of the Iron Regulatory Hormone Hepcidin by matriptase-2

Mitchell D Knutson. Nutr Rev. .

Abstract

Matriptase-2 is a recently identified membrane-bound, cell-surface serine protease expressed primarily in liver. Mutations in matriptase-2 in mice and humans cause iron-deficiency anemia that responds poorly to iron therapy. The poor response results from an inability to decrease hepcidin production during iron deficiency. Cell culture studies reveal that matriptase-2 inhibits hepcidin induction by cleaving membrane hemojuvelin, a potent activator of hepcidin transcription. As a novel suppressor of hepcidin expression, matriptase-2 emerges as a possible candidate for therapeutic interventions aimed at treating disorders of iron metabolism.

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