Vitamin K deficiency in CKD patients: a modifiable risk factor for vascular calcification?

Kidney Int. 2009 Jul;76(1):18-22. doi: 10.1038/ki.2009.126. Epub 2009 Apr 22.


The purpose of this review is to summarize currently available evidence implicating vitamin K in the pathogenesis of vascular calcification (VC), in particular arterial medial calcification. In doing so, we try to provide a rationale for an interventional clinical study testing whether vitamin K supplementation can retard VC or even affect cardiovascular mortality in chronic kidney disease patients. Additionally, we wish to give an overview of the current literature indicating potential adverse effects of long-term vitamin K antagonists in this population.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Calcinosis / etiology*
  • Humans
  • Kidney Failure, Chronic / complications*
  • Models, Biological
  • Risk Factors
  • Vascular Diseases / etiology*
  • Vitamin K Deficiency / complications*