Plasminogen activator inhibitor-1 and the circadian clock in metabolic disorders

Clin Exp Hypertens. 2009 May;31(3):208-19. doi: 10.1080/10641960902822468.


Plasma PAI-1 levels robustly fluctuate in a circadian manner and consequently contribute to hypofibrinolysis during the early morning. The circadian expression of PAI-1 gene is thought to be directly regulated by the circadian clock proteins such as CLOCK and BMAL1/BMAL2 which drive the endogenous biological clock. Plasma PAI-1 levels are increased in the beginning of the active phase in both diurnal humans and in nocturnal rodents, suggesting that the rhythmic PAI-1 expression is commonly indispensable for organisms. A series of our recent studies revealed that circadian clock proteins are important for hypofibrinolysis induced by metabolic disorders such as obesity and diabetes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ARNTL Transcription Factors
  • Animals
  • Basic Helix-Loop-Helix Transcription Factors / genetics
  • Basic Helix-Loop-Helix Transcription Factors / metabolism
  • CLOCK Proteins
  • Circadian Rhythm / genetics
  • Circadian Rhythm / physiology*
  • Diabetes Mellitus / genetics
  • Diabetes Mellitus / metabolism
  • Disease Models, Animal
  • Humans
  • Mice
  • Mutation / genetics
  • Obesity / genetics
  • Obesity / metabolism*
  • Plasminogen Activator Inhibitor 1 / genetics
  • Plasminogen Activator Inhibitor 1 / metabolism*
  • Trans-Activators / genetics
  • Trans-Activators / metabolism


  • ARNTL Transcription Factors
  • ARNTL protein, human
  • Arntl protein, mouse
  • Basic Helix-Loop-Helix Transcription Factors
  • Plasminogen Activator Inhibitor 1
  • Trans-Activators
  • CLOCK Proteins
  • CLOCK protein, human
  • Clock protein, mouse