The prevalence of fragile X in a sample of autistic individuals diagnosed using a standardized interview

J Am Acad Child Adolesc Psychiatry. 1991 Sep;30(5):825-30.


The study examined 75 autistic individuals who met DSM-III-R criteria for autistic disorder at 5 years of age. Diagnosis was based on information elicited using a standardized interview for autism. Two of 75 (2.7%) autistic subjects expressed the fragile X marker (Xq27.3) in 40% of cells counted and had other affected family members. Two additional subjects expressed the fragile X anomaly at low rates (1%). These rates are compared with those reported in other studies. Methodological differences, which may underlie the varying rates reported across studies, are discussed.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Autistic Disorder / diagnosis
  • Autistic Disorder / epidemiology*
  • Autistic Disorder / psychology
  • Baltimore / epidemiology
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Female
  • Fragile X Syndrome / diagnosis
  • Fragile X Syndrome / epidemiology*
  • Fragile X Syndrome / psychology
  • Humans
  • Incidence
  • Interview, Psychological
  • Male
  • Middle Aged
  • Personality Assessment