The isolation of endothelial progenitor cells changed our understanding of adult blood vessel formation. Recent studies have proven that EPCs functionally contribute to neovasculogenesis and reendothelization of damage blood vessels. It has been shown that patients with diabetes mellitus have decreased numbers of EPCs with impaired activities important to growth of blood vessels. It has been demonstrated that hypoglycemia cause abnormalities in EPCs proliferation, differentiation, adhesion and migration.