Autoantibody profiling for cancer detection

Clin Lab Med. 2009 Mar;29(1):31-46. doi: 10.1016/j.cll.2009.01.002.


Despite substantial progress in the understanding of the pathogenesis of cancer, the development and implementation of strategies for early cancer detection have lagged behind. Harnessing the immune response to tumor antigens is particularly useful for early detection because the immune response occurs early during tumor development and affords signal amplification with the end product, namely reactive immunoglobulins, being released into the circulation allowing easy access through the blood. This article presents recent developments in autoantibody profiling with a focus on proteomic approaches and applications to lung cancer.

Publication types

  • Review

MeSH terms

  • Antigens, Neoplasm / immunology*
  • Autoantibodies / blood*
  • Electrophoresis, Gel, Two-Dimensional
  • Humans
  • Neoplasms / diagnosis*
  • Peptide Library
  • Protein Array Analysis*
  • Proteomics / methods*
  • Tumor Suppressor Protein p53 / immunology


  • Antigens, Neoplasm
  • Autoantibodies
  • Peptide Library
  • Tumor Suppressor Protein p53