Allogeneic mesenchymal stem cells transplantation in treatment of multiple sclerosis

Mult Scler. 2009 May;15(5):644-6. doi: 10.1177/1352458509104590.


Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system. Umbilical cord derived mesenchymal stem cells are immunosuppressive. We transplanted mesenchymal stem cells in a patient with refractory progressive MS, and the disease course was stabilized after the transplantation. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Humans
  • Immunosuppression*
  • Magnetic Resonance Imaging
  • Mesenchymal Stem Cell Transplantation*
  • Middle Aged
  • Multiple Sclerosis, Chronic Progressive / immunology*
  • Multiple Sclerosis, Chronic Progressive / pathology
  • Multiple Sclerosis, Chronic Progressive / therapy*
  • Spinal Cord / pathology
  • Transplantation, Homologous