Comparison of in vitro activities of tigecycline with other antimicrobial agents against Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis in two university hospitals in Istanbul, Turkey

Chemotherapy. 2009;55(3):161-7. doi: 10.1159/000214144. Epub 2009 Apr 22.


Background: We compared the in vitro activities of tigecycline with those of other agents against 97 Streptococcus pneumoniae, 140 Haemophilus influenzae and 54 Moraxella catarrhalis strains isolated in two large university hospitals in Istanbul.

Methods: For analysis, the agar dilution method was used.

Results: For S. pneumoniae isolates, 32% were not susceptible to penicillin (28.9% intermediate and 3.1% resistant). Cefotaxime, telithromycin, moxifloxacin and linezolid were fully active. Tigecycline had a 90% minimum inhibitory concentration (MIC(90)) of 0.12 microg/ml. For H. influenzae, 8.57% were not susceptible to ampicillin, among which 8 possessed beta-lactamase (5.7%). Four (2.87%) H. influenzae isolates with beta-lactamase-negative and ampicillin-resistant phenotype were found. All isolates were susceptible to ceftriaxone, azithromycin, ciprofloxacin, levofloxacin and moxifloxacin. MIC(90) for tigecycline was 0.5 microg/ml. Of 54 M. catarrhalis isolates, 88.9% possessed beta-lactamase. Tigecycline and fluoroquinolones were highly active (MIC(90) < or =0.12 microg/ml).

Conclusions: Linezolid, telithromycin, newer fluoroquinolones and tigecycline all have excellent in vitro activities against the 3 respiratory pathogens.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Drug Resistance, Multiple, Bacterial
  • Haemophilus influenzae / drug effects*
  • Haemophilus influenzae / isolation & purification
  • Hospitals, University
  • Humans
  • Microbial Sensitivity Tests
  • Minocycline / analogs & derivatives*
  • Minocycline / pharmacology
  • Moraxella catarrhalis / drug effects*
  • Moraxella catarrhalis / isolation & purification
  • Streptococcus pneumoniae / drug effects*
  • Streptococcus pneumoniae / isolation & purification
  • Tigecycline
  • Turkey


  • Anti-Bacterial Agents
  • Tigecycline
  • Minocycline