Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 May;9(5):364-75.
doi: 10.1038/nri2532.

Intravascular immunity: the host-pathogen encounter in blood vessels

Michael J Hickey  1 , Paul Kubes
Affiliations
Review

Intravascular immunity: the host-pathogen encounter in blood vessels

Michael J Hickey et al. Nat Rev Immunol. 2009 May.

Abstract

The immune system provides an essential defence against invading pathogens. However, bacteria have evolved numerous strategies to overcome this defence, many of which facilitate systemic dissemination of the pathogen. Nevertheless, the host has evolved many mechanisms to detect and protect against pathogens in the vasculature. Recent studies using new imaging approaches and new mouse models are revealing previously unappreciated functions of this intravascular aspect of the immune system. In this Review, we summarize recent work in this field, highlighting in vivo imaging studies that examine the behaviour of both the immune system and bacteria in the highly dynamic microvasculature.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Exp Med. 2000 Oct 16;192(8):1205-11 - PubMed
    1. Thromb Haemost. 1999 Apr;81(4):613-7 - PubMed
    1. Liver. 1987 Apr;7(2):63-75 - PubMed
    1. Immunol Rev. 2001 Apr;180:86-99 - PubMed
    1. J Clin Invest. 2003 Apr;111(7):1011-20 - PubMed

Publication types

LinkOut - more resources