Role of the 585-nm pulsed dye laser in the treatment of acne in comparison with other topical therapeutic modalities

J Cosmet Laser Ther. 2009 Jun;11(2):118-24. doi: 10.1080/14764170902741329.


Background: Acne vulgaris is a disease of the pilosebaceous unit characterized by the development of inflammatory and/or non-inflammatory lesions that may progress to scars. The increase of bacterial resistance and adverse effects, the teratogenicity of retinoids and lack of response to usual therapies has led to the investigation of new therapeutic alternatives.

Objective: To evaluate the role of the pulsed dye laser in the treatment of acne in comparison with other topical therapeutic modalities.

Methods: We studied 45 patients with mild to moderate acne. Patients were randomly divided into three groups: group A received treatment with pulsed dye laser therapy every 2 weeks, group B received topical preparations and group C was subjected to chemical peeling using trichloroacetic acid 25%.

Results: At 12 weeks of treatment, there was a significant improvement of the lesions within each group with the best results seen in group A; however, no significant difference was detected between the three treatment protocols after the treatment period. Remission in the follow-up period was significantly higher in the first group.

Conclusions: Pulse dye laser therapy mainly improves the inflammatory lesions of acne with few adverse effects.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Acne Vulgaris / drug therapy
  • Acne Vulgaris / radiotherapy*
  • Adolescent
  • Adult
  • Chemexfoliation / methods*
  • Erythema / etiology
  • Female
  • Humans
  • Keratolytic Agents / adverse effects
  • Keratolytic Agents / therapeutic use*
  • Lasers, Dye / adverse effects
  • Lasers, Dye / therapeutic use*
  • Low-Level Light Therapy / adverse effects
  • Low-Level Light Therapy / instrumentation*
  • Male
  • Prospective Studies
  • Trichloroacetic Acid / therapeutic use
  • Young Adult


  • Keratolytic Agents
  • Trichloroacetic Acid