[Inflammation, adipokines and obesity]

Rev Med Interne. 2009 Sep;30(9):824-32. doi: 10.1016/j.revmed.2009.03.363. Epub 2009 Apr 25.
[Article in French]


In obese subjects, there is a "low grade" inflammatory state characterized by the moderate but chronic systemic rise of a panel of molecules (adipokines), which carry out, in addition to pro- or anti-inflammatory actions, several immune or metabolic functions, associated with a macrophagic infiltration in adipose tissue. These two factors provide a better understanding of the pathophysiology of obesity and its potential metabolic, cardiovascular or hepatic complications. A small or even moderate reduction of weight significantly reduces circulating inflammatory markers, modulates adipose tissue profile of inflammatory genes and the risks associated with obesity.

Publication types

  • Comparative Study
  • English Abstract
  • Review

MeSH terms

  • Adipokines / physiology*
  • Adipose Tissue / metabolism
  • Adipose Tissue / physiopathology
  • Humans
  • Inflammation / genetics
  • Inflammation / physiopathology*
  • Macrophages / metabolism
  • Macrophages / physiology
  • Obesity / complications
  • Obesity / diet therapy
  • Obesity / etiology
  • Obesity / genetics
  • Obesity / physiopathology*
  • Risk Factors
  • Weight Loss


  • Adipokines