Adult supratentorial low-grade glioma: long-term experience at a single institution

Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1401-7. doi: 10.1016/j.ijrobp.2009.01.010. Epub 2009 Apr 22.


Purpose: To report the long-term follow-up of a cohort of adult patients with supratentorial low-grade glioma treated at a single institution.

Methods and materials: A cohort of 145 adult patients treated at the London Regional Cancer Program between 1979 and 1995 was reviewed.

Results: With a median follow-up of 105 months, the median progression-free survival was 61 months (95% confidence interval, 53-77), and the median overall survival was 118 months (95% confidence interval, 93-129). The 10- and 20-year progression-free and overall survival rate was 18% and 0% and 48% and 22%, respectively. Cox regression analysis confirmed the importance of age, histologic type, presence of seizures, Karnofsky performance status, and initial extent of surgery as prognostic variables for overall and cause-specific survival. Function among long-term survivors without tumor progression was good to excellent for most patients.

Conclusion: Low-grade glioma is a chronic disease, with most patients dying of their disease. However, long-term survival with good function is possible. Survival is determined primarily by the disease factors with selection and timing of adjuvant treatments having less influence on outcome.

MeSH terms

  • Adult
  • Age Factors
  • Astrocytoma / drug therapy
  • Astrocytoma / mortality
  • Astrocytoma / pathology
  • Astrocytoma / radiotherapy*
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Headache / etiology
  • Humans
  • Karnofsky Performance Status
  • Male
  • Middle Aged
  • Oligodendroglioma / drug therapy
  • Oligodendroglioma / mortality
  • Oligodendroglioma / pathology
  • Oligodendroglioma / radiotherapy*
  • Quality of Life
  • Regression Analysis
  • Salvage Therapy / methods
  • Seizures / etiology
  • Supratentorial Neoplasms / drug therapy
  • Supratentorial Neoplasms / mortality
  • Supratentorial Neoplasms / pathology
  • Supratentorial Neoplasms / radiotherapy*
  • Survival Rate
  • Young Adult