Characterization of the Corynebacterium glutamicum deltapimB' deltamgtA double deletion mutant and the role of Mycobacterium tuberculosis orthologues Rv2188c and Rv0557 in glycolipid biosynthesis

J Bacteriol. 2009 Jul;191(13):4465-72. doi: 10.1128/JB.01729-08. Epub 2009 Apr 24.

Abstract

In this study, utilizing a Corynebacterium glutamicum DeltapimB' DeltamgtA double deletion mutant, we unequivocally assign the in vivo functions of Rv2188c as an Ac(1)PIM(1):mannosyltransferase (originally termed PimB'(Mt) [Mycobacterium tuberculosis PimB']) and Rv0557 as a GlcAGroAc(2):mannosyltransferase (originally termed PimB(Mt)), which we have reassigned as PimB(Mt) and MgtA(Mt), respectively, in Mycobacterium tuberculosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases / genetics
  • Adenosine Triphosphatases / metabolism*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Corynebacterium glutamicum / enzymology*
  • Corynebacterium glutamicum / genetics
  • Corynebacterium glutamicum / metabolism
  • Dolichol Monophosphate Mannose / metabolism
  • Gene Expression Regulation, Bacterial
  • Genetic Complementation Test
  • Glycolipids / biosynthesis*
  • Glycolipids / metabolism
  • Lipopolysaccharides / metabolism
  • Mannosyltransferases / genetics
  • Mannosyltransferases / metabolism*
  • Membrane Transport Proteins / genetics
  • Membrane Transport Proteins / metabolism*
  • Models, Biological
  • Sequence Deletion / genetics

Substances

  • Bacterial Proteins
  • Cfp32 protein, Mycobacterium tuberculosis
  • Glycolipids
  • Lipopolysaccharides
  • Membrane Transport Proteins
  • Dolichol Monophosphate Mannose
  • Mannosyltransferases
  • PimB protein, Mycobacterium tuberculosis
  • Adenosine Triphosphatases
  • MgtA protein, bacteria