Angiogenic monocytes: another colorful blow to endothelial progenitors

Am J Pathol. 2009 May;174(5):1594-6. doi: 10.2353/ajpath.2009.090198.


This Commentary provides perspective on a related article by Sun-Jin Kim and coworkers (Am J Pathol: 172 AJP08-0819), who assess the contribution of bone marrow-derived cells to tumor angiogenesis in a physiologic, non-myeloablative setting and conclude that the actual angiogenic cell type incorporated in the newly formed vessels is actually monocytes/macrophages.

Publication types

  • Comment

MeSH terms

  • Animals
  • Endothelium, Vascular / physiology*
  • Humans
  • Monocyte-Macrophage Precursor Cells / physiology*
  • Neoplasms / blood supply*
  • Neovascularization, Pathologic / metabolism*
  • Pericytes / cytology
  • Platelet Endothelial Cell Adhesion Molecule-1 / metabolism


  • Platelet Endothelial Cell Adhesion Molecule-1