Abstract
Rapamycin is widely used as a complete inhibitor of the mTORC1 nutrient-sensitive signaling complex. Using a novel ATP-competitive inhibitor named Torin1, we have found that many mTORC1 functions that regulate cap-dependent translation and autophagy are resistant to inhibition by rapamycin.
MeSH terms
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Animals
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Clinical Trials as Topic
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Humans
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Mechanistic Target of Rapamycin Complex 1
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Mice
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Models, Biological
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Multiprotein Complexes
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Protein Biosynthesis / drug effects
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Proteins
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Signal Transduction / drug effects
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Sirolimus / pharmacology*
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TOR Serine-Threonine Kinases
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Transcription Factors / antagonists & inhibitors*
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Transcription Factors / metabolism
Substances
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Multiprotein Complexes
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Proteins
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Transcription Factors
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Mechanistic Target of Rapamycin Complex 1
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TOR Serine-Threonine Kinases
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Sirolimus