Non-hydrolyzable RNA-peptide conjugates: a powerful advance in the synthesis of mimics for 3'-peptidyl tRNA termini

Angew Chem Int Ed Engl. 2009;48(22):4056-60. doi: 10.1002/anie.200900939.


Translation of specific small peptides on the ribosome can confer resistance to macrolide antibiotics. To reveal the molecular details of this and related phenomena, stable RNA-peptide conjugates that mimic peptidyl-tRNA would be desirable, especially for ribosome structural biology. A flexible solid-phase synthesis strategy now allows efficient access to these highly requested derivatives without restriction on the RNA and peptide sequences.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Hydrolysis
  • Molecular Mimicry*
  • Peptides / chemistry*
  • Protein Biosynthesis
  • RNA / chemistry*
  • RNA, Transfer, Amino Acyl / chemical synthesis*
  • RNA, Transfer, Amino Acyl / chemistry


  • Peptides
  • RNA, Transfer, Amino Acyl
  • tRNA, peptidyl-
  • RNA