Versatility of choline metabolism and choline-binding proteins in Streptococcus pneumoniae and commensal streptococci

FEMS Microbiol Rev. 2009 May;33(3):572-86. doi: 10.1111/j.1574-6976.2009.00172.x.


The pneumococcal choline-containing teichoic acids are targeted by cholinebinding proteins (CBPs), major surface components implicated in the interaction with host cells and bacterial cell physiology. CBPs also occur in closely related commensal species, Streptococcus oralis and Streptococcus mitis, and many strains of these species contain choline in their cell wall. Physiologically relevant CBPs including cell wall lytic enzymes are highly conserved between Streptococcus pneumoniae and S. mitis. In contrast, the virulence-associated CBPs, CbpA, PspA and PcpA, are S. pneumoniae specific and are thus relevant for the characteristic properties of this species.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism*
  • Choline / metabolism*
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Genetic Variation*
  • Molecular Sequence Data
  • Protein Binding
  • Sequence Analysis, DNA
  • Streptococcus mitis / genetics*
  • Streptococcus mitis / metabolism
  • Streptococcus oralis / genetics*
  • Streptococcus oralis / metabolism
  • Streptococcus pneumoniae / genetics*
  • Streptococcus pneumoniae / metabolism


  • Bacterial Proteins
  • DNA, Bacterial
  • Choline

Associated data

  • GENBANK/FJ824668