A Novel Codon Insert in Protease of Clade B HIV Type 1

AIDS Res Hum Retroviruses. 2009 May;25(5):547-50. doi: 10.1089/aid.2008.0310.

Abstract

A novel combination of three codon inserts in the pol coding region of HIV-1 RNA was identified in a highly antiretroviral experienced study subject with HIV-1 infection. A one codon insert was observed in the protease region between codon 40 and 41 simultaneously with a two codon insert present in the reverse transcriptase region at codon 69.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Base Sequence
  • HIV Infections / virology*
  • HIV Protease / genetics*
  • HIV Reverse Transcriptase / genetics
  • HIV-1 / genetics*
  • HIV-1 / isolation & purification
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Mutagenesis, Insertional*
  • RNA, Viral / genetics*
  • Sequence Analysis, DNA

Substances

  • RNA, Viral
  • reverse transcriptase, Human immunodeficiency virus 1
  • HIV Reverse Transcriptase
  • HIV Protease
  • p16 protease, Human immunodeficiency virus 1

Associated data

  • GENBANK/FJ159426