Heterologous prime-boost vaccinations for poverty-related diseases: advantages and future prospects

Expert Rev Vaccines. 2009 May;8(5):577-92. doi: 10.1586/erv.09.14.


Classical vaccination approaches, based on a single vaccine administered in a homologous prime-boost schedule and optimized to induce primarily neutralizing antibodies, are unlikely to be sufficiently efficacious to prevent TB, malaria or HIV infections. Novel vaccines, capable of inducing a more powerful immune response, in particular T-cell immunity, are desperately needed. Combining different vaccine modalities that are able to complement each other and induce broad and sustainable immunity is a promising approach. This review provides an overview of heterologous prime-boost vaccination modalities currently in development for the 'big three' poverty-related diseases and emphasizes the need for innovative vaccination approaches.

Publication types

  • Review

MeSH terms

  • HIV Infections / prevention & control
  • Humans
  • Immunization, Secondary / methods*
  • Malaria / prevention & control
  • Tuberculosis / prevention & control
  • Vaccination / methods*
  • Vaccines / administration & dosage*
  • Vaccines / immunology*
  • Vaccines, DNA / administration & dosage
  • Vaccines, DNA / immunology
  • Vaccines, Subunit / administration & dosage
  • Vaccines, Subunit / immunology


  • Vaccines
  • Vaccines, DNA
  • Vaccines, Subunit