Localized proton NMR spectroscopy of brain tumors using short-echo time STEAM sequences

J Comput Assist Tomogr. Nov-Dec 1991;15(6):915-22. doi: 10.1097/00004728-199111000-00002.

Abstract

Recent progress in localized proton NMR spectroscopy has been utilized to improve the spatial resolution and the metabolic specificity in a study of 19 patients with intracranial tumors. Selected examples demonstrate that short echo time stimulated echo acquisition mode sequences are able (a) to account for macroscopic tissue heterogeneity by reducing the volume of interest to 2-8 ml and (b) to facilitate a reasonable characterization of tumor metabolism by increasing the number of accessible metabolites. Proton NMR spectra were acquired within measuring times of 6.5 min on a 2.0 T whole-body system using the imaging headcoil.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aspartic Acid / analogs & derivatives
  • Aspartic Acid / metabolism
  • Astrocytoma / metabolism
  • Brain Neoplasms / metabolism*
  • Brain Neoplasms / secondary
  • Ependymoma / metabolism
  • Female
  • Glioma / metabolism
  • Glucose / metabolism
  • Humans
  • Lactates / metabolism
  • Magnetic Resonance Spectroscopy* / methods
  • Male
  • Middle Aged

Substances

  • Lactates
  • Aspartic Acid
  • N-acetylaspartate
  • Glucose