Regeneration of ischemic heart using hyaluronic acid-based injectable hydrogel

J Biomed Mater Res B Appl Biomater. 2009 Oct;91(1):163-71. doi: 10.1002/jbm.b.31386.


An injectable hydrogel was applied to regenerate a myocardial infarction and functional recovery of the heart. A myocardial infarction was induced in rat by circumflex artery ligation. A hyaluronic acid-based hydrogel was injected into the epicardium of the infarcted area. Then, cardiac functions and regeneration of the myocardium in sham-operated (SHAM), myocardial infarction (MI), and gel-injected group (GEL) (n = 6) were evaluated 4 weeks after the injection. Measurements of the thickness of the wall showed that the thickness in the GEL group increased by up to 200% compared with that in the MI group (p < 0.001). The infarcted area of the left ventricular in the GEL group decreased by 53% compared with the MI group (p < 0.001). The number of arterioles and capillaries in the border zone of the GEL group increased by 152% and 148%, whereas the apoptotic index decreased by 42% (p < 0.05). Measurement of the heart functions, such as ejection fraction, arterial elastance (Ea), dP/dt max, and dP/dt min, indicated that the injection of a hydrogel significantly facilitated the functional recovery compared with the MI group. Because of its simplicity, easy applicability, and a great regenerating potential, this injectable hydrogel promises as a treatment for myocardial infarction.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / administration & dosage
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / therapeutic use
  • Heart Ventricles / metabolism
  • Heart Ventricles / pathology
  • Hyaluronic Acid* / administration & dosage
  • Hyaluronic Acid* / chemistry
  • Hyaluronic Acid* / therapeutic use
  • Hydrogel, Polyethylene Glycol Dimethacrylate* / administration & dosage
  • Hydrogel, Polyethylene Glycol Dimethacrylate* / chemistry
  • Hydrogel, Polyethylene Glycol Dimethacrylate* / therapeutic use
  • Male
  • Materials Testing
  • Molecular Structure
  • Myocardial Infarction* / pathology
  • Myocardial Infarction* / therapy
  • Myocardium* / metabolism
  • Myocardium* / pathology
  • Rats
  • Rats, Sprague-Dawley
  • Regeneration / physiology*


  • Biocompatible Materials
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Hyaluronic Acid