The RB/E2F pathway and regulation of RNA processing

Biochem Biophys Res Commun. 2009 Jul 3;384(3):280-3. doi: 10.1016/j.bbrc.2009.04.107. Epub 2009 May 3.


The retinoblastoma tumor suppressor protein (RB) is inactivated in a majority of cancers. RB restricts cell proliferation by inhibiting the E2F family of transcription factors. The current model for RB/E2F function describes its role in regulating transcription at gene promoters. Whether the RB or E2F proteins might play a role in gene expression beyond transcription initiation is not well known. This review describes evidence that points to a novel role for the RB/E2F network in the regulation of RNA processing, and we propose a model as a framework for future research. The elucidation of a novel role of RB in RNA processing will have a profound impact on our understanding of the role of this tumor suppressor family in cell and developmental biology.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • E2F Transcription Factors / genetics
  • E2F Transcription Factors / metabolism*
  • Humans
  • RNA Processing, Post-Transcriptional*
  • RNA-Binding Proteins / metabolism*
  • Retinoblastoma Protein / genetics
  • Retinoblastoma Protein / metabolism*
  • Transcription, Genetic


  • E2F Transcription Factors
  • RNA-Binding Proteins
  • Retinoblastoma Protein