Platinum(II)-catalyzed intramolecular cyclization of o-substituted aryl alkynes through sp3 C-H activation

Angew Chem Int Ed Engl. 2009;48(22):3999-4001. doi: 10.1002/anie.200900368.

Abstract

Ring leader: PtCl(2) catalyzes intramolecular cyclization of o-isopropyl or o-benzyl aryl alkynes to give substituted indene derivatives with good yields and high selectivity. This reaction appears to proceed through an sp(3) C-H activation and 1,4-hydrogen migration pathway (see scheme).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Carbon / chemistry
  • Catalysis
  • Cyclization
  • Hydrogen / chemistry
  • Indenes / chemical synthesis*
  • Platinum / chemistry*

Substances

  • Alkynes
  • Indenes
  • Platinum
  • Carbon
  • Hydrogen