Antioxidant diterpenoids from the roots of Salvia barrelieri

Phytochem Anal. Jul-Aug 2009;20(4):320-7. doi: 10.1002/pca.1130.


Introduction: The phytochemical and biological studies carried out on Salvia species showed that their extracts and constituents have various biological activities.

Objective: The aim of this study was the isolation of diterpenoids from the roots of Salvia barrelieri Ettling and the determination of the antioxidant activity.

Methodology: Chromatographic methods were used for fractionation and isolation, respectively. Structure elucidation was established by spectroscopic methods. Five antioxidant assays were performed.

Results: Three new abietane diterpenoids barreliol, royleanone 12-methyl ether and 7-epi-salviviridinol, and six known diterpenoids, with a known dammarane triterpenoid, pyxinol were isolated. The absolute stereochemistry of pyxinol was confirmed by X-ray analysis.

Conclusion: Taxodione exhibited the highest antioxidant activity among the tested compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemistry*
  • Antioxidants / pharmacology*
  • Diterpenes / chemistry*
  • Diterpenes / pharmacology*
  • Dose-Response Relationship, Drug
  • Lipid Peroxidation / drug effects
  • Models, Molecular
  • Molecular Structure
  • Plant Roots / chemistry*
  • Salvia / chemistry*
  • beta Carotene / chemistry


  • Antioxidants
  • Diterpenes
  • beta Carotene