Obesity induced magnesium deficiency can be treated by vitamin D supplementation

J Pak Med Assoc. 2009 Apr;59(4):258-61.


Objective: To determine the effect of vitamin D injection on Serum Magnesium concentration in obese and non obese women.

Method: This Interventional study was performed on 82 women (17-50 years) which were randomly selected from general population of Tabriz city. They were assigned into two experimental groups. Obese group with stage 1 and 2 obesity and non obese group with normal weight. Weight was measured to the nearest 0.1 kg using a calibrated Seca scale. Height was measured using a cotton ruler which was pasted on the wall. Body mass index was calculated based on weight and height results. Biochemical parameters were measured before and after injection of 600000 IU doses of vitamin D. Serum Magnesium was measured calorimetrically and Serum 25 hydroxy vitamin D was estimated by Chemiluminescence Immune Assay method (CLIA).

Results: Baseline concentrations of serum Magnesium and 25 hydroxy vitamin D in obese individuals was lower than non obese individuals, the former being significant. Twenty seven percent of obese women versus 15% of non obese women were Magnesium deficient. Vitamin D injection caused a significant increase in serum Magnesium concentration in obese subjects but not in non obese subjects. There was also a significant increase of serum 25 hydroxy vitamin D in both groups. Mean elevation in serum Magnesium level among women who had Magnesium deficiency was higher than women with Magnesium adequacy (P < 0.05).

Conclusion: Low serum Magnesium concentration in obese individuals can be modified by vitamin D injection.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Body Mass Index
  • Dietary Supplements / adverse effects
  • Female
  • Humans
  • Magnesium / blood*
  • Magnesium Deficiency / blood
  • Magnesium Deficiency / drug therapy
  • Magnesium Deficiency / etiology*
  • Middle Aged
  • Obesity / blood*
  • Obesity / complications*
  • Treatment Outcome
  • Vitamin D / administration & dosage*
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • Vitamins / administration & dosage
  • Vitamins / adverse effects
  • Young Adult


  • Vitamins
  • Vitamin D
  • 25-hydroxyvitamin D
  • Magnesium