Plasma levels of monocyte chemotactic protein 3 and beta-nerve growth factor increase with amnestic mild cognitive impairment

Cell Mol Immunol. 2009 Apr;6(2):143-7. doi: 10.1038/cmi.2009.20.


A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment (MCI). In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 (MCP-3), and beta-nerve growth factor (beta-NGF) in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and beta-NGF may be useful in differentiating subtypes of MCI.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Amnesia / blood
  • Amnesia / diagnosis
  • Amnesia / immunology*
  • Biomarkers / blood*
  • Chemokine CCL7 / blood*
  • Cognition Disorders / blood
  • Cognition Disorders / immunology*
  • Diagnosis, Differential
  • Female
  • Humans
  • Male
  • Nerve Growth Factor / blood*
  • Psychological Tests
  • Severity of Illness Index


  • Biomarkers
  • Chemokine CCL7
  • Nerve Growth Factor