Effect of Bacopa monniera on liver and kidney toxicity in chronic use of opioids

Phytomedicine. 2009 Oct;16(10):897-903. doi: 10.1016/j.phymed.2009.03.005. Epub 2009 Apr 29.


In the present study, we investigated the protective effect of Bacopa monniera, an indigenous Ayurvedic medicinal plant in India, against morphine-induced liver and kidney toxicity in rats. Morphine intoxicated rats received 10-160 mg/kg body weight of morphine hydrochloride intraperitoneally for 21 days. Bacopa monniera Extract (BME) pretreated rats were administered with BME (40 mg/kg) orally once a day 2 h before the injection of morphine for 21 days. Pretreatment with BME has shown to possess a significant protective effect against morphine-induced liver and kidney functions in terms of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase, lactate dehydrogenases and gamma-glutamyl transferase activities and urea, creatinine and uric acid level respectively. Histopathological changes of liver and kidney were also in accordance with the biochemical findings. The results of this study indicate that Bacopa monniera extract exerted a protection against morphine-induced liver and kidney toxicity.

MeSH terms

  • Animals
  • Bacopa* / chemistry
  • Chemical and Drug Induced Liver Injury / pathology
  • Chemical and Drug Induced Liver Injury / prevention & control*
  • Chromatography, High Pressure Liquid
  • Drug Evaluation, Preclinical
  • Kidney / pathology
  • Kidney Diseases / chemically induced
  • Kidney Diseases / pathology
  • Kidney Diseases / prevention & control*
  • Liver / pathology
  • Male
  • Morphine / adverse effects*
  • Morphine Dependence / drug therapy
  • Phytotherapy*
  • Plant Extracts / chemistry
  • Plant Extracts / therapeutic use
  • Rats
  • Rats, Wistar


  • Plant Extracts
  • Morphine