Breaking a temporal barrier: signalling crosstalk regulates the initiation of border cell migration

Nat Cell Biol. 2009 May;11(5):536-8. doi: 10.1038/ncb0509-536.

Abstract

Correct timing of developmental events is crucial for generating a normal organism. During oogenesis in Drosophila melanogaster, migration of border cells occurs in a defined temporal window and requires Jak/Stat and steroid hormone signalling. The initiation of border-cell migration is now shown to be timed by Jak/Stat-mediated downregulation of the BTB domain transcriptional regulator Abrupt, which acts as a negative regulator of steroid hormone signalling.

Publication types

  • News

MeSH terms

  • Animals
  • CCAAT-Enhancer-Binding Proteins / metabolism
  • Cell Movement / physiology*
  • Drosophila Proteins / metabolism
  • Drosophila Proteins / physiology*
  • Drosophila melanogaster
  • Ecdysone / metabolism
  • Female
  • Gene Expression Regulation / physiology
  • Janus Kinases / metabolism
  • Models, Biological
  • Nuclear Proteins / physiology*
  • Oogenesis / physiology*
  • Ovarian Follicle / cytology*
  • Ovarian Follicle / physiology
  • Protein Binding / physiology
  • Receptors, Steroid / metabolism
  • STAT Transcription Factors / metabolism
  • Signal Transduction / physiology*
  • Transcription Factors / metabolism

Substances

  • CCAAT-Enhancer-Binding Proteins
  • Drosophila Proteins
  • Nuclear Proteins
  • Receptors, Steroid
  • STAT Transcription Factors
  • TAI protein, Drosophila
  • Transcription Factors
  • ab protein, Drosophila
  • ecdysone receptor
  • slbo protein, Drosophila
  • Ecdysone
  • Janus Kinases
  • hop protein, Drosophila