Spatiotemporal image correlation spectroscopy measurements of flow demonstrated in microfluidic channels

J Biomed Opt. Mar-Apr 2009;14(2):024014. doi: 10.1117/1.3088203.

Abstract

Accurate blood flow measurements during surgery can improve an operation's chance of success. We developed near-infrared spatio-temporal image spectroscopy (NIR-STICS), which has the potential to make blood flow measurements that are difficult to accomplish with existing methods. Specifically, we propose the technique and we show feasibility on phantom measurements. NIR-STICS has the potential of measuring the fluid velocity in small blood vessels (less than 1 mm in diameter) and of creating a map of blood flow rates over an area of approximately 1 cm(2). NIR-STICS employs near-infrared spectroscopy to probe inside blood vessel walls and spatiotemporal image correlation spectroscopy to directly-without the use of a model-extract fluid velocity from the fluctuations within an image. We present computer simulations and experiments on a phantom system that demonstrate the effectiveness of NIR-STICS.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Algorithms*
  • Arteries / physiology*
  • Blood Flow Velocity / physiology*
  • Computer-Aided Design
  • Equipment Design
  • Equipment Failure Analysis
  • Microfluidics / instrumentation*
  • Phantoms, Imaging
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Spectroscopy, Near-Infrared / instrumentation*
  • Spectroscopy, Near-Infrared / methods