The sequence-structure relationship and protein function prediction

Curr Opin Struct Biol. 2009 Jun;19(3):357-62. doi: 10.1016/ Epub 2009 May 4.


An incomplete understanding of protein sequence/structure/function relationships causes many difficulties for prediction methods. The highly complex nature of these relationships is a consequence of the interplay between physics and evolution that has been studied using a wide array of experimental and theoretical techniques. We review recent findings relating to conservation of sequence, structure and function and discuss their use in developing improved prediction methods.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Conformation
  • Proteins / chemistry*
  • Proteins / metabolism*


  • Proteins