Network of European studies of genes in growth (NESTEGG)

Horm Res. 2009 Apr;71 Suppl 2:48-54. doi: 10.1159/000192436. Epub 2009 Apr 29.

Abstract

The network of European studies of genes in growth (NESTEGG) is an international growth genomics project, focusing on the birth size phenotypes of small for gestational age (SGA) and idiopathic short stature. Seven hundred controls and 1,275 cases with their parents have been recruited. Detailed clinical histories and auxological measurements are recorded in a clinical database. Candidate gene studies are being undertaken with the study DNA samples. These genetic data will be used to explore associations with the clinical phenotypes of short stature and SGA birth size, and, in a subset, response to growth hormone (GH) therapy. This article describes the study methodology and reviews the association of the exon 3-deleted genotype of the GH receptor with GH responsiveness in GH-treated children born SGA.

Publication types

  • Review

MeSH terms

  • Body Size / genetics*
  • Europe
  • Genome, Human*
  • Genomics / trends*
  • Growth Disorders / drug therapy
  • Growth Disorders / genetics*
  • Hormone Replacement Therapy
  • Human Growth Hormone / genetics*
  • Human Growth Hormone / metabolism
  • Human Growth Hormone / therapeutic use
  • Humans
  • Infant, Newborn
  • Infant, Small for Gestational Age*

Substances

  • Human Growth Hormone