Caffeine-induced psychosis

CNS Spectr. 2009 Mar;14(3):127-9. doi: 10.1017/s1092852900020101.

Abstract

As a competitive adenosine antagonist, caffeine affects dopamine transmission and has been reported to worsen psychosis in people with schizophrenia and to cause psychosis in otherwise healthy people. We report of case of apparent chronic caffeine-induced psychosis characterized by delusions and paranoia in a 47-year-old man with high caffeine intake. The psychosis resolved within 7 weeks after lowering caffeine intake without use of antipsychotic medication. Clinicians might consider the possibility of caffeinism when evaluating chronic psychosis.

Publication types

  • Case Reports

MeSH terms

  • Adenosine A1 Receptor Antagonists
  • Adenosine A2 Receptor Antagonists
  • Caffeine / adverse effects*
  • Central Nervous System Stimulants / adverse effects*
  • Humans
  • Male
  • Middle Aged
  • Paranoid Disorders / chemically induced
  • Paranoid Disorders / psychology
  • Psychoses, Substance-Induced / psychology*
  • Psychoses, Substance-Induced / therapy

Substances

  • Adenosine A1 Receptor Antagonists
  • Adenosine A2 Receptor Antagonists
  • Central Nervous System Stimulants
  • Caffeine