Regioselective and sequential reactivity of activated 2,5-diketopiperazines

J Pept Sci. 2009 Jul;15(7):474-8. doi: 10.1002/psc.1139.


The electrophilic reactivity of Boc-DKPs has been studied. Thanks to Boc activation, the opening ability of carbonyl lactam groups is enhanced. According to experimental conditions, this enabled the synthesis of Boc-amino acid derivatives or original dipeptides via a regioselective and sequential way.

MeSH terms

  • Amino Acids / chemical synthesis
  • Amino Acids / chemistry
  • Diketopiperazines / chemistry*
  • Dipeptides / chemical synthesis
  • Dipeptides / chemistry
  • Molecular Structure
  • Stereoisomerism


  • Amino Acids
  • Diketopiperazines
  • Dipeptides