Glutathione peroxidase in early and advanced Parkinson's disease

J Neurol Neurosurg Psychiatry. 1991 Aug;54(8):679-82. doi: 10.1136/jnnp.54.8.679.


A defective antioxidant scavenging system plays a major role in one of the theories of the pathogenesis of Parkinson's disease. The aim of this study was to investigate whether there is a general difference in antioxidant activity between early and advanced cases of Parkinson's disease. Twenty five recently diagnosed patients, without any clinical fluctuations (group A), and 25 patients in a late phase of the disease with severe fluctuations in response to levodopa therapy (group B) were included in the study. Erythrocyte glutathione peroxidase was determined as a measure of antioxidant activity and significantly lower values were found in group B than in group A. Regression analyses in groups A and B showed significant correlation between glutathione peroxidase and duration of disease, but not between glutathione peroxidase and age of patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Erythrocytes / enzymology
  • Female
  • Glutathione Peroxidase / physiology*
  • Humans
  • Male
  • Middle Aged
  • Neurologic Examination
  • Parkinson Disease / diagnosis
  • Parkinson Disease / enzymology*
  • Selenium / blood*


  • Glutathione Peroxidase
  • Selenium