Treatment of postconcussional symptoms with CDP-choline

J Neurol Sci. 1991 Jul:103 Suppl:S39-42. doi: 10.1016/0022-510x(91)90007-t.


To evaluate the efficacy of cytidine diphosphoryl choline (CDP-choline) in treating postconcussional symptoms for one month after mild to moderate closed head injury (CHI), we completed a preliminary double blind placebo-controlled study. Fourteen young men admitted to the neurosurgery service after sustaining mild to moderate CHI were randomized to oral CDP-choline (1 g) and placebo control groups which were matched for age, education and severity of impaired consciousness. Baseline (prior to discharge) and one month examinations consisted of a structured postconcussional symptom interview and neuropsychological tests. Results (Wilcoxon test) showed that CDP-choline produced a greater reduction of postconcussional symptoms than placebo (P less than 0.005). Analysis of the neuropsychological findings revealed a significantly greater improvement in recognition memory for designs in the CDP-choline treated patients (P less than 0.02) whereas other changes in test performance did not differ for the two groups. Pending replication in a larger series of patients, our findings suggest that CDP-choline may be effective in treating sequelae of mild to moderate CHI.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Brain Concussion / drug therapy*
  • Brain Concussion / psychology
  • Cytidine Diphosphate Choline / therapeutic use*
  • Humans
  • Memory / drug effects
  • Middle Aged
  • Neuropsychological Tests
  • Time Factors


  • Cytidine Diphosphate Choline