Distribution of parvalbumin immunoreactivity in the human brain

J Neurol. 1991 Sep;238(6):320-2. doi: 10.1007/BF00315329.


The cellular distribution of parvalbumin-like immunoreactivity (PA-LI) in the human brain was investigated by peroxidase-antiperoxidase methods using antiserum to rat skeletal muscle parvalbumin. PA-LI was present in non-pyramidal neurons of the cerebral cortices, stellate cells, basket cells and Purkinje cells in cerebellar cortices, and neurons of some nuclei in human brain stem; the distribution of PA-LI in human brain was very similar to that in rat brain. These results indicate that PA-LI is widely distributed in a specific subpopulation of neurons of the human brain.

MeSH terms

  • Aged
  • Animals
  • Brain Stem / chemistry*
  • Cerebellar Cortex / chemistry*
  • Cerebral Cortex / chemistry*
  • Hippocampus / chemistry
  • Humans
  • Immunoenzyme Techniques
  • Inferior Colliculi / chemistry
  • Medulla Oblongata / chemistry
  • Mesencephalon / chemistry
  • Middle Aged
  • Parvalbumins / analysis*
  • Rats
  • Rats, Inbred Strains
  • Reference Values
  • Thalamus / chemistry
  • Zona Reticularis / chemistry


  • Parvalbumins