Abstract
Introduction:
The purpose of this study was to examine the effect of a pulpal revascularization procedure for immature necrotic teeth with apical periodontitis.
Methods:
Twelve patients, each with an immature permanent tooth with chronic or acute apical periodontitis, were recruited. A triantibiotic mix (ciprofloxacin, metronidazole, and minocycline) was used to disinfect the pulp for 1 week. Then a blood clot was created in the canal, over which grey mineral trioxide aggregate was placed. Patients were recalled periodically.
Results:
Six patients dropped from the study (as a result of pain or failure to induce bleeding after canal disinfection) and instead received a standard apexification procedure. Another 3 patients did not attend any recall appointments. The remaining teeth (n = 3) were found to exhibit complete root development, with a positive response to pulp testing.
Conclusions:
Revascularization could be effective for managing immature permanent teeth with apical periodontitis with appropriate case selection.
MeSH terms
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Aluminum Compounds / therapeutic use
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Anti-Bacterial Agents / administration & dosage
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Anti-Infective Agents / administration & dosage
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Bicuspid / pathology
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Blood Coagulation / physiology
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Calcium Compounds / therapeutic use
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Child
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Ciprofloxacin / administration & dosage
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Dental Pulp / blood supply*
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Dental Pulp / physiopathology
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Dental Pulp Cavity / blood supply
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Dental Pulp Necrosis / therapy*
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Drug Combinations
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Female
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Follow-Up Studies
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Guided Tissue Regeneration / methods
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Humans
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Incisor / pathology
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Male
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Metronidazole / administration & dosage
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Minocycline / administration & dosage
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Neovascularization, Physiologic / physiology*
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Odontogenesis / physiology
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Oxides / therapeutic use
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Periapical Periodontitis / therapy*
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Root Canal Filling Materials / therapeutic use
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Root Canal Preparation / methods
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Root Canal Therapy / methods*
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Silicates / therapeutic use
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Tooth Apex / physiopathology*
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Treatment Outcome
Substances
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Aluminum Compounds
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Anti-Bacterial Agents
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Anti-Infective Agents
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Calcium Compounds
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Drug Combinations
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Oxides
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Root Canal Filling Materials
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Silicates
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mineral trioxide aggregate
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Metronidazole
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Ciprofloxacin
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Minocycline