The role of CD4 T cell help for CD8 CTL activation

Biochem Biophys Res Commun. 2009 Jul 10;384(4):405-8. doi: 10.1016/j.bbrc.2009.04.134. Epub 2009 May 3.


CD4 T cells play an important role in the initiation and persistence of CD8 T cells responses. In this review, we report on and evaluate the mechanisms by which CD4 T cells contribute to activation of CD8 T cells and the signal pathways of the down-streaming events after CD4 T cell help.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • Cross-Priming
  • Cytotoxicity, Immunologic*
  • Dendritic Cells / immunology
  • Humans
  • Lymphocyte Activation*
  • Signal Transduction
  • T-Lymphocytes, Cytotoxic / immunology*