Circadian regulation of DNA excision repair: implications for chrono-chemotherapy

Cell Cycle. 2009 Jun 1;8(11):1665-7. doi: 10.4161/cc.8.11.8707. Epub 2009 Jun 9.

Abstract

The mammalian circadian system synchronizes organisms' daily cyclical physiology from gene expression to gross behavioral patterns. A new study from our group suggests that DNA repair is also intimately linked to circadian rhythm. Since the repair of DNA lesions contributes to the resistance of chemotherapy with DNA damaging agents such as cisplatin, understanding the fundamental molecular mechanism regulating DNA repair pathways is important for cancer therapy. Here we review the significance of the connection linking the circadian clock with nucleotide excision repair and discuss potential implications for chemotherapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • ARNTL Transcription Factors
  • Antineoplastic Agents / administration & dosage*
  • Basic Helix-Loop-Helix Transcription Factors / genetics
  • Basic Helix-Loop-Helix Transcription Factors / metabolism
  • Circadian Rhythm / genetics*
  • Circadian Rhythm / physiology
  • Cryptochromes
  • DNA Repair*
  • DNA-Binding Proteins / metabolism
  • Drug Chronotherapy
  • Flavoproteins / genetics
  • Flavoproteins / metabolism
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Period Circadian Proteins
  • Replication Protein A / genetics
  • Replication Protein A / metabolism
  • Transcription Factor TFIIH / genetics
  • Transcription Factor TFIIH / metabolism
  • Transcription, Genetic
  • Xeroderma Pigmentosum Group A Protein / genetics
  • Xeroderma Pigmentosum Group A Protein / metabolism

Substances

  • ARNTL Transcription Factors
  • ARNTL protein, human
  • Antineoplastic Agents
  • Basic Helix-Loop-Helix Transcription Factors
  • Cryptochromes
  • DNA-Binding Proteins
  • Flavoproteins
  • Intracellular Signaling Peptides and Proteins
  • PER1 protein, human
  • Period Circadian Proteins
  • RPA1 protein, human
  • Replication Protein A
  • XPA protein, human
  • Xeroderma Pigmentosum Group A Protein
  • Transcription Factor TFIIH