Work interruptions and their contribution to medication administration errors: an evidence review

Worldviews Evid Based Nurs. 2009;6(2):70-86. doi: 10.1111/j.1741-6787.2009.00151.x. Epub 2009 Apr 29.


Background: In many surveys, nurses cite work interruptions as a significant contributor to medication administration errors.

Objectives: To review the evidence on (1) nurses' interruption rates, (2) characteristics of such work interruptions, and (3) contribution of work interruptions to medication administration errors.

Search strategy: CINHAL (1982-2008), MEDLINE (1980-2008), EMBASE (1980-2008), and PSYCINFO (1980-2008) were searched using a combination of keywords and reference lists.

Selection criteria: Original studies published in English using nurses as participants and for which work interruption frequencies are reported.

Data collection and analysis: Studies were identified and selected by two reviewers. Once selected, a single reviewer extracted data and assessed quality based on established criteria. Data on nurses' work interruption rates were synthesized to produce a pooled estimate.

Results: Twenty-three studies were considered for analysis. A rate of 6.7 work interruptions per hour was obtained, based on 14 studies that reported both an observation time and work interruption frequency. Work interruptions are mostly initiated by nurses themselves through face-to-face interactions and are of short duration. A lower proportion of interruptions resulted from work system failures such as missing medication. One nonexperimental study documented the contribution of work interruptions to medication administration errors with evidence of a significant association (p = 0.01) when errors related to time of administration are excluded from the analysis. Conceptual shortcomings were noted in a majority of reviewed studies, which included the absence of theoretical underpinnings and a diversity of definitions of work interruptions.

Conclusions: Future studies should demonstrate improved methodological rigor through a precise definition of work interruptions and reliability reporting to document work interruption characteristics and their potential contribution to medication administration errors, considering the limited evidence found. Meanwhile, efforts should be made to reduce the number of work interruptions experienced by nurses.

Publication types

  • Review

MeSH terms

  • Evidence-Based Nursing*
  • Humans
  • Interprofessional Relations
  • Medication Errors / methods*
  • Medication Errors / prevention & control*
  • Personnel Staffing and Scheduling*
  • Workload*