The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes

Obes Rev. 2009 Sep;10(5):519-26. doi: 10.1111/j.1467-789X.2009.00569.x. Epub 2009 Apr 21.


Uncoupling proteins (UCPs) belong to the family of mitochondrial transporter proteins that may uncouple the transport of protons across the inner mitochondrial membrane from electron transport and the synthesis of ATP from ADP, hence generating heat rather than energy. In mammals, more than five family members have been identified, including UCP1, UCP2, UCP3, UCP4 (or BMCP1/UCP5) and UCP5. The UCPs may play an important role in energy homeostasis and have become prominent in the fields of thermogenesis, obesity, diabetes and free-radical biology and have been considered candidate genes for obesity and insulin resistance. They have been as important potential targets for treatment of aging, degenerative diseases, diabetes and obesity. Recently, a series of studies showed the polymorphisms of UCPs gene association with the fat metabolism, obesity and diabetes. This review summarizes data supporting the roles of UCP2 and UCP3 in energy dissipation, as well as the genetic variety association with fat metabolism, obesity and diabetes in humans.

Publication types

  • Review

MeSH terms

  • 3' Untranslated Regions
  • Diabetes Mellitus / genetics*
  • Diabetes Mellitus / metabolism
  • Exons
  • Haplotypes
  • Humans
  • INDEL Mutation
  • Ion Channels / genetics*
  • Ion Channels / metabolism
  • Lipid Metabolism*
  • Mitochondrial Proteins / genetics*
  • Mitochondrial Proteins / metabolism
  • Obesity / genetics*
  • Obesity / metabolism
  • Polymorphism, Single Nucleotide
  • Promoter Regions, Genetic
  • Uncoupling Protein 2
  • Uncoupling Protein 3


  • 3' Untranslated Regions
  • Ion Channels
  • Mitochondrial Proteins
  • UCP2 protein, human
  • UCP3 protein, human
  • Uncoupling Protein 2
  • Uncoupling Protein 3